A recent study explored whether using vaginal estrogen therapy, a treatment for menopause-related symptoms like vaginal dryness and discomfort, is safe for women who have survived breast cancer. There has been concern that this therapy might increase the risk of breast cancer coming back or lead to higher mortality rates. To investigate this, researchers analyzed data from eight observational studies involving tens of thousands of breast cancer survivors.
The findings were reassuring. Among breast cancer survivors who used vaginal estrogen, there was no increased risk of cancer returning, either locally or in other parts of the body. The odds of breast cancer coming back were found to be lower than expected, with no evidence linking vaginal estrogen use to higher rates of breast cancer-related deaths or overall deaths. Specifically, the analysis showed no significant increase in breast cancer recurrence, breast cancer-specific mortality, or general mortality in these women.
These results suggest that vaginal estrogen therapy may be a safe option for managing menopausal symptoms in breast cancer survivors. However, since these findings are based on observational studies, women considering this treatment should consult their healthcare providers to discuss their individual circumstances and any potential risks.